Plaque heterogeneity and the spatial distributions of its components dictate drug-coated balloon therapy

Plaque heterogeneity and the spatial distributions of its components dictate drug-coated balloon therapy

Blog Article

Abstract Drug-coated balloon (DCB) angioplasty is one of the potential approaches to alleviating in-stent restenosis and treating peripheral artery disease.An in-silico model has been developed for sirolimus drug eluted from an inflated balloon in a patient-specific arterial cross-section consisting of fibrous tissue, fibrofatty tissue, dense calcium, necrotic core, and healthy tissue.The convection-diffusion-reaction equation represents the transport of drug, while drug binding, both specific and non-specific, can be modelled as a reaction process.

The Brinkman equations describe the interstitial flow in porous tissue.An image processing technique Plein air - Accessoires - Bas is leveraged for reconstructing the computational domain.The Marker and Cell, and Immersed Boundary Methods are used to solve the set of governing equations.

The no-flux interface condition and convection do amplify the tissue content, and the regions of dense calcium and necrotic core limited to or extremely close to the interface pose a clinical threat to DCB therapy.Simulations predict the effects of the positioning and clustering of plaque components in the domain.This study demands extensive intravascular ultrasound-derived virtual histology (VH-IVUS) imaging to understand the plaque morphology and determine the relative positions of different Fan Guard plaque compositions about the lumen-tissue interface, which have a significant impact on arterial pharmacokinetics.